600吨土霉素生产课程设计

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1、摘要 摘要 土霉素，又名地霉素，氧四环素，属四环素类抗生素，为广谱抑菌剂，许 多立克次体属、支原体属、衣原体属、螺旋体对土霉素敏感。它是 1949 年由美 国开发的一种抗生素。 土霉素是一个典型的利用生物工程技术生产的产品，生产工艺涉及种子培 养、发酵、酸化、提取、过滤、脱色、结晶、离心和干燥等重要的单元操作和 工程概念。本次课程设计进行的是酸化、提炼、干燥工段的工艺设计，该说明 书主要对土霉素车间的生产工艺流程进行了简单的概括，并且对酸化、提炼和 干燥工段给予了详细介绍。本说明书给出了 600t/a 土霉素车间的物料衡算的详 细计算过程和总结，并将生产中各部分的数据制成了表格。最后，在既得数

2、据 和结合工艺流程的基础上绘制了本工段工艺管道及仪表流程的 PID 图。 关键词：土霉素；物料衡算；工艺流程；提炼工段 Abstract Abstract Oxytetracycline, also known as Geotrichum, oxytetracycline, belonging to the tetracycline antibiotics, as a broad-spectrum antimicrobial agent, a lot of Rickettsia, mycoplasma, chlamydia, helicoid of oxytetracycline sensit

3、ive. It is in 1949 by the development of an antibiotic. Oxytetracycline is a typical use of biological engineering technology products, the production process involves seed cultivation, fermentation, acidification, extraction, filtration, decoloration, crystallization, centrifugation and drying and

4、other important unit operation and engineering concepts. The curriculum design is acidification, refining, drying in the process design, the specification the main workshop of oxytetracycline production process were summarized briefly, and the acidification, refining and drying section is introduced in detail. This manual gives a detailed calculation process of material balance calculation and 600t/a oxytetracycline workshop summary, and each part of the production data in the table is made. Fi